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ChemicalBook--->CAS DataBase List--->2452464-73-0

2452464-73-0

2452464-73-0 Structure

2452464-73-0 Structure
IdentificationBack Directory
[Name]

IL-17A inhibitor 1
[CAS]

2452464-73-0
[Synonyms]

LY-3533028
IL-17A inhibitor 1
1,2,5-Oxadiazole-3-carboxamide, N-[(S)-(4,4-difluorocyclohexyl)[7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)-1-imidazolidinyl]ethyl]imidazo[1,2-b]pyridazin-2-yl]methyl]-4-methyl-
[Molecular Formula]

C24H27F5N8O4
[MDL Number]

MFCD34474218
[MOL File]

2452464-73-0.mol
[Molecular Weight]

586.51
Chemical PropertiesBack Directory
[density ]

1?+-.0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

11.52±0.46(Predicted)
[color ]

Off-white to yellow
Hazard InformationBack Directory
[Biological Activity]

IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells[1]. IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%)[1].
[storage]

Store at -20°C
[References]

[1]. COATES DAVID ANDREW, et al. IMIDAZO[1,2-B]PYRIDAZINE IL-17A INHIBITORS. Patent WO2020146194.
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