| Identification | Back Directory | [Name]
Benzamide, 4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-N-[4-[[(trans-4-methylcyclohexyl)amino]carbonyl]-2-(2-methylpropoxy)phenyl]-3-(2-methylpropoxy)- | [CAS]
2440087-54-5 | [Synonyms]
Benzamide, 4-[[3-(2-hydroxyethoxy)-4-nitrobenzoyl]amino]-N-[4-[[(trans-4-methylcyclohexyl)amino]carbonyl]-2-(2-methylpropoxy)phenyl]-3-(2-methylpropoxy)- | [Molecular Formula]
C38H48N4O9 | [MOL File]
2440087-54-5.mol | [Molecular Weight]
704.81 |
| Hazard Information | Back Directory | [Description]
ERX-41 is an inducer of endoplasmic reticulum (ER) stress.1 It increases the thermal stability of lysosomal acid lipase when used at a concentration of 10 μM in the cellular thermal shift assay (CETSA) but does not inhibit lysosomal acid lipase enzymatic activity at 30 μM. ERX-41 (1 μM) increases ER tubule width, eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3/PERK) and inositol-requiring enzyme 1α (IRE1α) phosphorylation, and splicing of the gene encoding X-box binding protein 1 (XBP1) in SUM149 triple-negative breast cancer (TNBC) cells. It reduces tumor volume and weight in several patient-derived xenograft (PDX) mouse models of TNBC when administered at a dose of 10 mg/kg. | [References]
1. Liu, X., Viswanadhapalli, S., Kumar, S., et al. Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress Nat. Cancer 3(7),866-884(2022). |
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