| Identification | Back Directory | [Name]
Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- | [CAS]
2387524-59-4 | [Synonyms]
NF-κΒ activator 1
Benzoic acid, 3-[2-[(2-fluorophenyl)amino]-4-thiazolyl]- | [Molecular Formula]
C16H11FN2O2S | [MOL File]
2387524-59-4.mol | [Molecular Weight]
314.33 |
| Chemical Properties | Back Directory | [Boiling point ]
532.5±60.0 °C(Predicted) | [density ]
1.427±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 125 mg/mL (397.67 mM; Need ultrasonic) | [form ]
Solid | [pka]
3.84±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
NF-κβ activator 1 is a potent NF-κβ activator with an EC50 of 0.9 μM. NF-κβ activator 1 induces superoxide dismutase (SOD)2 mRNA expression[1].
NF-κβ activator 1 (compound 32) (1 μM; 6 hours) induces SOD2 mRNA expression in SH-SY5Y neuroblastoma cells[1]. | [References]
[1]. Mathew B, et al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-?B activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952. |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
|