Identification | Back Directory | [Name]
Garenoxacin | [CAS]
223652-90-2 | [Synonyms]
Garenoxacin mesylate [USAN] BMS284756 (Mesylate hydrate) Garenoxacin mesylate hydrate Garenoxacin mesylate monohydrate >=98% (HPLC) 1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate (R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate Garenoxacin mesylate hydrate
1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate | [Molecular Formula]
C23H20F2N2O4.CH4O3S.H2O | [MDL Number]
MFCD12031996 | [MOL File]
223652-90-2.mol | [Molecular Weight]
540.53 |
Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO:100.0(Max Conc. mg/mL);185.0(Max Conc. mM) Water:12.5(Max Conc. mg/mL);23.13(Max Conc. mM) | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: 10mg/mL, clear (warmed) |
Hazard Information | Back Directory | [Uses]
Antibacterial agent. | [Biological Activity]
Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows th at garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1. |
|
|