| Identification | Back Directory | [Name]
MPEG11-CH2CH2COONHS | [CAS]
2207596-93-6 | [Synonyms]
MPEG11-CH2CH2COONHS
4,7,10,13,16,19,22,25,28,31,34,37-Dodecaoxaoctatriacontanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C30H55NO16 | [MDL Number]
MFCD13184970 | [MOL File]
2207596-93-6.mol | [Molecular Weight]
685.75 |
| Chemical Properties | Back Directory | [Boiling point ]
684.3±65.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [form ]
Liquid | [color ]
Colorless to light yellow | [InChIKey]
ZMXRHHJWXLKMTL-UHFFFAOYSA-N | [SMILES]
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC |
| Hazard Information | Back Directory | [Biological Activity]
m-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
|