| Identification | Back Directory | [Name]
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE | [CAS]
218137-86-1 | [Synonyms]
C75
FAS inhibitor C75
(C-75
C75 >=98% (HPLC), powder
3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE
TRANS-4-CARBOXY-5-OCTYL-3-METHYLENEBUTYROLACTONE
3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo-
C75(4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylicacid)
TRANS-TETRAHYDRO-3-METHYLENE-2-OXO-5-N-OCTYL-4-FURANCARBOXYLIC ACID | [Molecular Formula]
C14H22O4 | [MDL Number]
MFCD03265452 | [MOL File]
218137-86-1.mol | [Molecular Weight]
254.32 |
| Chemical Properties | Back Directory | [Boiling point ]
432.1±45.0 °C(Predicted) | [density ]
1.08±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 18 mg/mL
| [form ]
solid
| [pka]
3.08±0.40(Predicted) | [color ]
off-white
|
| Hazard Information | Back Directory | [Uses]
C75 has been used:
- as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
- as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
- as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide
| [Definition]
ChEBI: 4-methylene-2-octyl-5-oxo-3-oxolanecarboxylic acid is a gamma-lactone. | [Biochem/physiol Actions]
C75 helps to increase the cancer‐killing capability of ionizing radiation. |
|
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Sigma-Aldrich
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Musechem
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www.musechem.com |
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DC Chemicals
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