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ChemicalBook--->CAS DataBase List--->2165322-94-9

2165322-94-9

2165322-94-9 Structure

2165322-94-9 Structure
IdentificationBack Directory
[Name]

USP25 and 28 inhibitor AZ-1
[CAS]

2165322-94-9
[Synonyms]

AZ-1;AZ 1;AZ1
USP25/28 inhibitor AZ1
USP25 and 28 inhibitor AZ-1
Ethanol, 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]-
[Molecular Formula]

C17H16BrF4NO2
[MDL Number]

MFCD32201047
[MOL File]

2165322-94-9.mol
[Molecular Weight]

422.21
Chemical PropertiesBack Directory
[Boiling point ]

478.5±40.0 °C(Predicted)
[density ]

1.488±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: ≥ 250 mg/mL (592.12 mM); Water: < 0.1 mg/mL (insoluble)
[form ]

Solid
[pka]

14.74±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

AZ1 is a potent and selective dual USP25 & USP28 deubiquitinase (DUBs) inhibitor (USP25/28 IC50 = 0.62/0.7 nM by Ub-Rh110 assay) th at induces HCT116 cellular c-Myc degradation (20-100 μM for 3h or 60 μM for 0.3-3h). AZ1 exhibits antiproliferation activity in cancer cultures (IC50 ≤20 μM; HCT116HT29 and SW480) and anti-tumor efficacy in an orthotopic model of lung SCC tumours in mice in vivo (125 mg/kg or 375 mg/kg i.p. once every three days6 injections total).
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