Identification | Back Directory | [Name]
USP25 and 28 inhibitor AZ-1 | [CAS]
2165322-94-9 | [Synonyms]
AZ-1;AZ 1;AZ1 USP25/28 inhibitor AZ1 USP25 and 28 inhibitor AZ-1 Ethanol, 2-[[[5-bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]- | [Molecular Formula]
C17H16BrF4NO2 | [MDL Number]
MFCD32201047 | [MOL File]
2165322-94-9.mol | [Molecular Weight]
422.21 |
Chemical Properties | Back Directory | [Boiling point ]
478.5±40.0 °C(Predicted) | [density ]
1.488±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 250 mg/mL (592.12 mM); Water: < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
14.74±0.10(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Biological Activity]
AZ1 is a potent and selective dual USP25 & USP28 deubiquitinase (DUBs) inhibitor (USP25/28 IC50 = 0.62/0.7 nM by Ub-Rh110 assay) th at induces HCT116 cellular c-Myc degradation (20-100 μM for 3h or 60 μM for 0.3-3h). AZ1 exhibits antiproliferation activity in cancer cultures (IC50 ≤20 μM; HCT116HT29 and SW480) and anti-tumor efficacy in an orthotopic model of lung SCC tumours in mice in vivo (125 mg/kg or 375 mg/kg i.p. once every three days6 injections total). |
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Company Name: |
InvivoChem Gold
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Tel: |
13549236410 |
Website: |
https://www.invivochem.cn/ |
Company Name: |
Henan Alfachem Co.,Ltd.
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0371-0371-55051623 18137891487 |
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http://www.is0513.com/supplier/14555231/ |
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