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ChemicalBook--->CAS DataBase List--->215294-98-7

215294-98-7

215294-98-7 Structure

215294-98-7 Structure
IdentificationBack Directory
[Name]

5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
[CAS]

215294-98-7
[Synonyms]

X-34
X-34 >=90% (HPLC)
Benzoic acid, 3,3'-(1,4-phenylenedi-2,1-ethenediyl)bis[6-hydroxy-
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
[Molecular Formula]

C24H18O6
[MOL File]

215294-98-7.mol
[Molecular Weight]

402.4
Chemical PropertiesBack Directory
[Boiling point ]

669.9±55.0 °C(Predicted)
[density ]

1.448±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

DMSO: 2.0mg/mL, clear
[form ]

Solid
[pka]

2.85±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Biological Activity]

Fluorescentamyloid-specific dye''X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimerμs disease (AD).''X-34 is a fluorescentamyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.
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