| Identification | Back Directory | [Name]
L-ABRINE | [CAS]
21339-55-9 | [Synonyms]
ABRINE
Precasin
L-ABRINE
H-METRP-OH
ABRINE, L-
N-ME-TRP-OH
(S)-Indoximod
H-Trp(1-Me)-OH
N-ME-TRYPTOPHAN
N-METHYLTRYPTOPHAN
1-methyltryptophan
1-methyl-l-tryptopha
L-1-Methyltryptophan
1-METHYL-L-TRYPTOPHAN
N-METHYL-L-TRYPTOPHAN
1-Methyl-L-tryptophane
N-A-METHYL-L-TRYPTOPHAN
L-(-)-1-Methyltryptophan
N-ALPHA-METHYL-L-TRYPTOPHAN
Abrine/1-Methyl-L-tryptophan
1-Methyl-L-tryptophan
N ALPHA-METHYL-L(+)-TRYPTOPHAN
1-Methyl-L-tryptophan USP/EP/BP
2-amino-3-(1-methylindol-3-yl)propanoic acid
2-amino-3-(1-methylindol-3-yl)propionic acid
2-azanyl-3-(1-methylindol-3-yl)propanoic acid
(αS)-1-Methyl-α-amino-1H-indole-3-propanoic acid
(αS)-α-Amino-1-methyl-1H-indole-3-propanoic acid
(2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
(S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
(2S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid | [EINECS(EC#)]
208-388-5 | [Molecular Formula]
C12H14N2O2 | [MDL Number]
MFCD00005645 | [MOL File]
21339-55-9.mol | [Molecular Weight]
218.25 |
| Chemical Properties | Back Directory | [Melting point ]
>300 °C (dec.)(lit.)
| [Boiling point ]
429.3±35.0 °C(Predicted) | [density ]
1.28 | [storage temp. ]
2-8°C | [solubility ]
Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly, Sonicated), DMSO (Slightly） | [form ]
White to off-white powder. | [pka]
2.26±0.10(Predicted) | [color ]
Off-White to Pale Beige | [optical activity]
[α]24/D 8.0°, c = 2 in acetic acid |
| Hazard Information | Back Directory | [Uses]
Competitive inhibitor of indoleamine 2,3-dioxygenase (IDO). | [Definition]
ChEBI: 1-methyl-L-tryptophan is an indolyl carboxylic acid. | [reaction suitability]
reaction type: solution phase peptide synthesis | [in vivo]
(S)-Indoximod (5 mg/day, i.p. for 3 weeks) reverses the Bacillus Calmette-Guerin (BCG)-induced neurotoxicity in mice[3].
(S)-Indoximod (200 mg/kg, oral gavage) shows delayed, lasts longer renoprotective effect than D isomer, and increases survival in the IRI rat model[4].
(S)-Indoximod (1-9 mg/kg, i.p.) reverses cognitive, anxiety, and depressive-like behavior in bile duct ligation (BDL) rats[5].
| Animal Model: | Bile duct ligation (BDL) rats[5] | | Dosage: | 1-9 mg/kg | | Administration: | i.p., After the rats recovered for 7 days from BDL surgery. | | Result: | Increased the sucrose preference.
Prevents the increased number of buried marbles.
Improved learning and memory function.
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