| Identification | Back Directory | [Name]
butizide | [CAS]
2043-38-1 | [Synonyms]
S-3500
Su-6187
Butizid
Modenol
Saltucin
butizide
Eunephran
Butizidum
Buthiazide
Thiabutazide
Isobutylhydrochlorothiazide
6-chloro-3,4-dihydro-3-isobutyl-1,2,4-benzothiadiazine-7-sulphonamide 1,1-dioxide
6-chloro-3-isobutyl-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
6-Chloro-3,4-dihydro-3-(2-Methylpropyl)-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide
6-chloro-3-(2-methylpropyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-(2-methylpropyl)-, 1,1-dioxide | [EINECS(EC#)]
218-048-8 | [Molecular Formula]
C11H16ClN3O4S2 | [MDL Number]
MFCD00867351 | [MOL File]
2043-38-1.mol | [Molecular Weight]
353.85 |
| Chemical Properties | Back Directory | [Melting point ]
214-217°C | [Boiling point ]
562.7±60.0 °C(Predicted) | [density ]
1.4221 (rough estimate) | [refractive index ]
1.6100 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.01±0.40(Predicted) | [color ]
White to Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Originator]
Saltucin,Boehringer Mannheim,W. Germany,1961 | [Uses]
Diuretic and antihypertensive. | [Definition]
ChEBI: Butizide is a benzothiadiazine. | [Manufacturing Process]
Chlorsulfonic acid and 3-chloroaniline react to give an intermediate which
when treated with ammonia yields 5-chloro-2,4-disulfamylaniline.
20 g of 5-chloro-2,4-disulfamylaniline in 15 cc of diethyleneglycol-dimethyl
ether with 0.9 g of isovaleraldehyde are reacted in the presence of 0.5 cc of a
saturated solution of hydrochloric acid in ethyl acetate at 80°-90°C. The
reaction mixture is concentrated under reduced pressure, an oily product
precipitates on the addition of water, the latter is decanted and ethanol added
to the remaining oil. 3-Isobutyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-
benzothiadiazine-1,1-dioxide crystallizes and, after recrystallization from
dimethylformamide and water, melts at 241°-245°C. | [Therapeutic Function]
Diuretic, Antihypertensive |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|