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ChemicalBook--->CAS DataBase List--->2033173-01-0

2033173-01-0

2033173-01-0 Structure

2033173-01-0 Structure
IdentificationBack Directory
[Name]

IDO/TDO-IN-1
[CAS]

2033173-01-0
[Synonyms]

IDO/TDO-IN-1
IDO/TDO IN 1,IDO/TDOIN1
[Molecular Formula]

C25H24FN5
[MDL Number]

MFCD32174301
[MOL File]

2033173-01-0.mol
[Molecular Weight]

413.49
Chemical PropertiesBack Directory
[Boiling point ]

664.5±55.0 °C(Predicted)
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

5.63±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]

IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].

[References]

[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

2033173-01-0 suppliers list
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Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: TargetMol Chemicals Inc.  
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Website: https://www.targetmol.cn/
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