| Identification | Back Directory | [Name]
2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione | [CAS]
19956-53-7 | [Synonyms]
Lucidone
2-[(1Z,2E)-1-Hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione
4-Cyclopentene-1,3-dione,2-[(2E)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-, (2Z)-
(2E)-2-[(2E)-1-Hydroxy-3-phenyl-2-propen-1-ylidene]-4-methoxy-4-cyclopentene-1,3-dione | [Molecular Formula]
C15H12O4 | [MDL Number]
MFCD20260390 | [MOL File]
19956-53-7.mol | [Molecular Weight]
256.25 |
| Hazard Information | Back Directory | [Uses]
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM)[1][2]. | [Definition]
ChEBI: Lucidone is an olefinic compound. It is functionally related to a cinnamic acid. | [in vivo]
Lucidone (1 mg/kg; intracranial injection; 3 times for 1 week) significantly increases the survival rate and body weight of DENV-infected mice[2]. | Animal Model: | DENV-infected ICR mice[2] | | Dosage: | 0.4 mg/kg, 1 mg/kg | | Administration: | Intracranial injection; 3 times dose at day 2, 4, 6 after DENV infection | | Result: | Increased the survival rate and body weight of DENV-infected mice on day 7. |
| [IC 50]
p38 MAPK; JNK; p50; p65; COX-2; NF-κB; iNOS; IKK | [References]
[1] Senthil Kumar KJ, et aL. Lucidone inhibits iNOS and COX-2 expression in LPS-induced RAW 264.7 murine macrophage cells via NF-kappaB and MAPKs signaling pathways. Planta Med. 2009 Apr;75(5):494-500. DOI:10.1055/s-0029-1185309
[2] Chen WC, et al. Lucidone suppresses dengue viral replication through the induction of heme oxygenase-1. Virulence. 2018 Jan 1;9(1):588-603. DOI:10.1080/21505594.2017.1421893 |
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BioBioPha Co., Ltd.
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