Identification | Back Directory | [Name]
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea | [CAS]
196868-63-0 | [Synonyms]
PQ401 CS-764 PQ401, >=98% PQ-401; PQ 401 PQ401 hydrochloride IGF-1R Inhibitor II IGF-1R Inhibitor II, PQ401 N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)- IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem 1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea 1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)- PQ 401
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea PQ401 | [Molecular Formula]
C18H16ClN3O2 | [MDL Number]
MFCD00160558 | [MOL File]
196868-63-0.mol | [Molecular Weight]
341.796 |
Hazard Information | Back Directory | [Uses]
Potent inhibitor of insulin-like growth factor I receptor (IGF-IR) signalling and breast cancer cell growth in culture and in vivo. | [Definition]
ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines. | [Biological Activity]
Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo . | [in vivo]
a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1]. | [storage]
Store at +4°C | [References]
[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86. [2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79. |
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