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ChemicalBook--->CAS DataBase List--->196868-63-0

196868-63-0

196868-63-0 Structure

196868-63-0 Structure
IdentificationBack Directory
[Name]

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
[CAS]

196868-63-0
[Synonyms]

PQ401
CS-764
PQ401, >=98%
PQ-401; PQ 401
PQ401 hydrochloride
IGF-1R Inhibitor II
IGF-1R Inhibitor II, PQ401
N-(5-chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-
IGF-1R Inhibitor II, PQ401 - CAS 196868-63-0 - Calbiochem
1-(5-Chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea
1-(5-Chloro-2-Methoxyphenyl)-3-(2-Methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)urea
Urea, N-(5-chloro-2-Methoxyphenyl)-N'-(2-Methyl-4-quinolinyl)-
PQ 401 N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea
N-(5-Chloro-2-methoxyphenyl)-N'-(2-methyl-4-quinolinyl)-urea PQ401
[Molecular Formula]

C18H16ClN3O2
[MDL Number]

MFCD00160558
[MOL File]

196868-63-0.mol
[Molecular Weight]

341.796
Chemical PropertiesBack Directory
[density ]

1.370±0.06 g/cm3 (20 ºC 760 Torr)
[storage temp. ]

2-8°C
[solubility ]

DMSO: >10mg/mL
[form ]

White solid
[color ]

white
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25
[Safety Statements ]

45
[RIDADR ]

UN 2811 6.1/PG 3
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Potent inhibitor of insulin-like growth factor I receptor (IGF-IR) signalling and breast cancer cell growth in culture and in vivo.
[Definition]

ChEBI: 1-(5-chloro-2-methoxyphenyl)-3-(2-methyl-4-quinolinyl)urea is a member of quinolines.
[Biological Activity]

Insulin-like growth factor receptor (IGF1R) inhibitor. Suppresses IGF-stimulated IGF-IR autophosphorylation with an IC 50 value of 12 μ M. Inhibits growth of MCF-7 breast cancer cells in vitro and in vivo .
[in vivo]

a treatment with pq401 triple per week reduced the growth rate of mcneua cells implanted into mice [1].
[storage]

Store at +4°C
[References]

[1]. gable kl, maddux ba, penaranda c, zavodovskaya m, campbell mj, lobo m, robinson l, schow s, kerner ja, goldfine id, youngren jf. diarylureas are small-molecule inhibitors of insulin-like growth factor i receptor signaling and breast cancer cell growth. mol cancer ther. 2006 apr;5(4):1079-86.
[2]. wang h, qin j, gong s, feng b, zhang y, tao j. insulin-like growth factor-1 receptor-mediated inhibition of a-type k(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 pathways, independently of akt. endocrinology. 2014 jan;155(1):168-79.
Spectrum DetailBack Directory
[Spectrum Detail]

IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-Nμ-(2-methylquinolin-4-yl)urea(196868-63-0)1HNMR
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