| Identification | Back Directory | [Name]
Vocacapsaicin | [CAS]
1931116-86-7 | [Synonyms]
CA-008
Vocacapsaicin
1-Piperidinecarboxylic acid, 2-[(methylamino)methyl]-, 2-methoxy-4-[[[(6E)-8-methyl-1-oxo-6-nonen-1-yl]amino]methyl]phenyl ester | [Molecular Formula]
C26H41N3O4 | [MOL File]
1931116-86-7.mol | [Molecular Weight]
459.62 |
| Hazard Information | Back Directory | [Description]
Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief. | [Mode of action]
Vocacapsaicin(CA-008, Conentric Analgesics) – an investigational TRPV agonist being studied for long-lasting pain – works through the same TRPV1 agonism mechanism but its localized delivery is thought to minimize activation of a large array of neurons, such as capsaicin topical products. | [References]
[1] TARRA KNOTTS. Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models[J]. Journal of Orthopaedic Research?, 2022, 40 10: 2281-2293. DOI:10.1002/jor.25271.
[2]. Olivia Higgins, et al. Analgesics of the Future: The Potential of Vocacapsaicin Injections for Knee Pain. 12 Articles in Volume 21, Issue #2. |
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