| Identification | Back Directory | [Name]
ZM 323881 hydrochloride | [CAS]
193000-39-4 | [Synonyms]
ZM 323881 HCl, >=99%
ZM 323881 hydrochloride USP/EP/BP
ZM323881 hydrochloride HCL ZM-323881
Phenol, 4-fluoro-2-methyl-5-[[7-(phenylmethoxy)-4-quinazolinyl]amino]-, hydrochloride (1:1) | [Molecular Formula]
C22H19ClFN3O2 | [MOL File]
193000-39-4.mol | [Molecular Weight]
411.857 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | [form ]
Powder | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Hydrochloride salt of ZM 323881, a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) with application towards cancer treatments. | [Definition]
ChEBI: ZM 323881 hydrochloride is a hydrochloride obtained by combining ZM 323881 with one molar equivalent of hydrochloric acid. It has a role as a vascular endothelial growth factor receptor antagonist and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It contains a ZM 323881(1+). | [Biological Activity]
ZM323881 is a selective inhibitor of VEGFR-2 with an IC50 value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβFGFR1EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC50 value of 8 nM.''ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol). It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR). | [storage]
Desiccate at +4°C |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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