| Identification | Back Directory | [Name]
desmethylanethol trithione | [CAS]
18274-81-2 | [Synonyms]
ACS 1
Adt-Oh
Anethole impurity 2
desmethylanethol trithione
Anethole Trithione impurity 2
5-(4-hydroxyphenyl)dithiole-3-thione
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione
3H-1,2-Dithiole-3-thione, 5-(4-hydroxyphenyl)- | [Molecular Formula]
C9H6OS3 | [MDL Number]
MFCD20922704 | [MOL File]
18274-81-2.mol | [Molecular Weight]
226.34 |
| Chemical Properties | Back Directory | [Melting point ]
191-192 °C | [Boiling point ]
431.4±55.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMF: 15 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
9.78±0.30(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Description]
ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. It can be readily esterified with other moieties.1 For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 (Item No. 13045).2 ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 (Item No. 17100), which selectively increases mitochondrial H2S levels.3 ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.3,4 | [Uses]
is used in method for preventing or treating diseases associated with administration of VEGFR and/or VEGF inhibitor. |
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