18228-17-6

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18228-17-6 Structure

Identification	Back Directory
[Name] NAPHTHOL AS-E PHOSPHATE
[CAS] 18228-17-6
[Synonyms] NASEP kg-501 KD-501 NAPHTHOL AS-E PHOSPHATE 2-naphthol-AS-E-phosphate KG-501(NaphtholAS-Ephosphate) NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY 2-NAPHTHOL-AS-E-PHOSPHATE;NAPHTHOL AS-E PHOSPHATE 3-hydroxy-2-(hydroxymethyl)-2-methyl-1-phenyl-1-propanone N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide 2-Naphthalenecarboxamide, N-(4-chlorophenyl)-3-(phosphonooxy)- [3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501
[EINECS(EC#)] 242-106-1
[Molecular Formula] C17H13ClNO5P
[MDL Number] MFCD00042718
[MOL File] 18228-17-6.mol
[Molecular Weight] 377.72

Chemical Properties	Back Directory
[density ] 1.567±0.06 g/cm3(Predicted)
[storage temp. ] Keep in dark place,Inert atmosphere,2-8°C
[solubility ] DMSO: soluble
[form ] A crystalline solid
[pka] 1.04±0.30(Predicted)
[color ] White to light yellow
[BRN ] 6664478

Safety Data	Back Directory
[WGK Germany ] 3
[F ] 8-10-21

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[Uses]

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

[Biological Activity]

Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.

[in vitro]

Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.

[in vivo]

Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.

[target]

Target	Value
CREB ()

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