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ChemicalBook--->CAS DataBase List--->1820708-73-3

1820708-73-3

1820708-73-3 Structure

1820708-73-3 Structure
IdentificationBack Directory
[Name]

SKA-121
[CAS]

1820708-73-3
[Synonyms]

SKA-121
SKA121,SKA 121
Naphth[2,1-d]oxazol-2-amine, 5-methyl-
SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
[Molecular Formula]

C12H10N2O
[MDL Number]

MFCD31630822
[MOL File]

1820708-73-3.mol
[Molecular Weight]

198.22
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
[form ]

powder
[color ]

brown to dark gray
Hazard InformationBack Directory
[Biochem/physiol Actions]

SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).
[storage]

Store at -20°C
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