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ChemicalBook--->CAS DataBase List--->1818294-40-4

1818294-40-4

1818294-40-4 Structure

1818294-40-4 Structure
IdentificationBack Directory
[Name]

Thiol-PEG6-t-butyl ester
[CAS]

1818294-40-4
[Synonyms]

HS-PEG6-CH2CH2-Boc
HS-PEG6-CH2CH2COOtBu
SH-PEG6-CH2CH2COOtBu
Thiol-PEG6-t-butyl ester
[Molecular Formula]

C19H38O8S
[MDL Number]

MFCD26127815
[MOL File]

1818294-40-4.mol
[Molecular Weight]

426.57
Chemical PropertiesBack Directory
[Boiling point ]

488.8±45.0 °C(Predicted)
[density ]

1.072±0.06 g/cm3(Predicted)
[pka]

9?+-.0.10(Predicted)
Hazard InformationBack Directory
[Biological Activity]

HS-PEG6-CH2CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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