| Identification | Back Directory | [Name]
HDAC6-IN-1 | [CAS]
1815580-06-3 | [Synonyms]
SKLB-23bb
HDAC6-IN-1
Butanamide, N-hydroxy-4-[2-methoxy-5-[methyl(2-methyl-4-quinazolinyl)amino]phenoxy]- | [Molecular Formula]
C21H24N4O4 | [MDL Number]
MFCD30533607 | [MOL File]
1815580-06-3.mol | [Molecular Weight]
396.44 |
| Chemical Properties | Back Directory | [density ]
1.271±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: Soluble | [form ]
A solid | [pka]
9.32±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SKLB-23bb is an orally bioavailable and selective HDAC6 inhibitor with IC50 of less than 100 nM in most cell lines tested; it can be used to disrupt microtubule activity. | [in vitro]
SKLB-23bb has toxic effects at low submolar levels in a range of solid and hematological tumor cell lines. Unlike reported selective HDAC6 inhibition, SKLB-23bb is more potent against solid tumors. SKLB-23bb selectively inhibits intracellular HDAC6, but its antitumor activity is independent of HDAC6. It can bind to the colchicine site of β-tubulin and is a microtubule polymerization inhibitor. SKLB-23bb also can arrest tumor cells in the G2-M phase and induce apoptosis. | [in vivo]
In a solid tumor model, oral administration of SKLB-23bb can effectively inhibit tumor growth. It has favorable pharmacokinetic properties and is orally active. | [target]
| Target | Value | HDAC6
(Cell-based assay) | <100 nM |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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