| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 1 mg/ml; Ethanol/H20 (95:5): 2 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| Hazard Information | Back Directory | [Description]
Protectin conjugates in tissue regeneration 1 (PCTR1) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; ).1 DHA is oxidized to 16S,17S-epoxy-protectin, which is then converted to PCTR1 by glutathione S-transferase.1,2 PCTR1 levels increase during resolution of acute microbial-induced peritonitis in mice.3 PCTR1 (30 ng, i.p.) administration 12 hours post-infection increases macrophage numbers and activity and shortens the resolution phase of inflammation by 57%. It also reduces the levels of PGE2 , PGD2 , and TXB2 in peritoneal exudates.
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Store at -20°C | [References]
1. Rodriguez, A.R., and Spur, B.W. Total synthesis of pro-resolving and tissue-regenerative protectin sulfido-conjugates Tetrahedron Lett. 56(42),5811-5815(2015).
2. Aursnes, M., Tungen, J.E., Colas, R.A., et al. Synthesis of the 16S,17S-epoxyprotectin intermediate in the biosynthesis of protectins by human macrophages J. Nat. Prod. 8(12),2924-2931(2015).
3. Ramon, S., Dalli, J., Sanger, J.M., et al. The protectin PCTR1 is produced by human M2 macrophages and enhances resolution of infectious inflammation Am. J. Pathol. 186(4),962-973(2016). |
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