| Identification | Back Directory | [Name]
9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- | [CAS]
1801856-93-8 | [Synonyms]
KL044
KL-044
KL 044
9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- | [Molecular Formula]
C21H14ClN3O | [MDL Number]
MFCD33548809 | [MOL File]
1801856-93-8.mol | [Molecular Weight]
359.81 |
| Chemical Properties | Back Directory | [Boiling point ]
563.3±50.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (277.92 mM; Need ultrasonic) | [form ]
Solid | [pka]
11.00±0.70(Predicted) | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Biological Activity]
KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1].
KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1]. | [storage]
Store at -20°C | [References]
[1]. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97. |
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