| Identification | Back Directory | [Name]
4-BETA-HYDROXYCHOLESTEROL | [CAS]
17320-10-4 | [Synonyms]
4-Hydroxy Cholesterol
4--Hydroxy Cholestrol
cholest-5-ene-3,4-diol
4β-Hydroxy Cholesterol
Cholesterol Impurity 30
4-BETA-HYDROXYCHOLESTEROL
4β-Hydroxycholesterol-[d5]
4β-Hydroxycholesterol-[d4]
Cholest-5-ene-3beta,4beta-diol
cis-delta5-Cholestene-3,4-diol
5-CHOLESTEN-3-BETA, 4-BETA-DIOL
Cholest-5-ene-3,4-diol, (3b,4b)-
3beta,4beta-Dihydroxycholest-5-ene
cis-3,4-Dihydroxy-delta5-cholestene
(3beta,4beta)-Cholest-5-ene-3,4-diol
Cholest-5-ene-3,4-diol, (3beta,4beta)- | [Molecular Formula]
C27H46O2 | [MDL Number]
MFCD00201408 | [MOL File]
17320-10-4.mol | [Molecular Weight]
402.65 |
| Chemical Properties | Back Directory | [Melting point ]
172-174°C | [Boiling point ]
500.2±30.0 °C(Predicted) | [density ]
1.03±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
14.32±0.70(Predicted) | [color ]
White to Pale Beige |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential | [Uses]
A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker. | [Definition]
ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in
he human circulation. | [Biological Activity]
4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1]. | [storage]
Store at -20°C | [References]
[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43. |
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