| Identification | Back Directory | [Name]
RUBOXISTAURIN HYDROCHLORIDE | [CAS]
169939-93-9 | [Synonyms]
Ruboxistaurin HCl
Ruboxistaurin(LY333531HCl)
Ruboxistaurin Hydrochloride
LY 333531 hydrochloride - Ruboxistaurin
(9S)-9-[(DiMethylaMino)Methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-DiMethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione Hydrochloride
(S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione monohydrochloride | [Molecular Formula]
C28H29ClN4O3 | [MDL Number]
MFCD00940226 | [MOL File]
169939-93-9.mol | [Molecular Weight]
505.01 |
| Chemical Properties | Back Directory | [alpha ]
D25 -28.7° (c = 1.0 in ethanol) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
orange-red |
| Hazard Information | Back Directory | [Description]
LY333531 is an inhibitor of PKCβ (IC50s = 4.7 and 5.9 nM for PKCβ1 and PKCβ2, respectively). It is selective for PKCβ1 and PKCβ2 over PKCα, -γ, -δ, -ε, -ζ, and -η (IC50s = 360, 300, 250, >100,000, and 52 nM, respectively). LY333531 also inhibits glycogen synthase kinase 3β (GSK3β; IC50 = 39.4 nM). It inhibits neutrophil extracellular trap (NET) formation induced by phorbol 12-myristate 13-acetate (PMA; ) in primary human neutrophils when used at a concentration of 1 μM. LY333531 increases the mechanical nociceptive threshold in a rat model of diabetic hyperalgesia induced by streptozotocin (STZ; ). | [Uses]
A protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial growth factor (VEGF). It is used in treatment of diabetic microvascular comp | [Uses]
Ruboxistaurin is a protein kinase C (PKC) β inhibitor, exhibits significant anti-angiogenic activity that reduces the response of vascular endothelial cells to stimulation by vascular endothelial grow
th factor (VEGF). Ruboxistaurin is used in treatment of diabetic microvascular complications. |
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ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878 |
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http://www.is0513.com/ShowSupplierProductsList15061/0.htm |
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