| Identification | Back Directory | [Name]
(R)-1-N-Boc-2-(hydroxymethyl)piperazine | [CAS]
169448-87-7 | [Synonyms]
Nicotinamide Impurity 202
(R)-1-Boc-2-(hyroxyMethyl)piperazine
(R)-1-Boc-2-Hydroxymethyl-piperazine
(R)-1-N-BOC-2-HYDROXYMETHYLPIPERAZINE HCl
(R)-1-Boc-2-Hydroxymethyl-piperazine ,98%
(S)-1-Boc-2-Hydroxymethyl-piperazine ,98%
tert-butyl (R)-2-(hydroxymethyl)piperazine-1-carboxylate
(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate
tert-Butyl (2R)-2-(hydroxymethyl)piperazin-1-carboxylate
tert-Butyl (2R)-2-(hydroxymethyl)piperazine-1-carboxylate
2-Methyl-2-propanyl(2R)-2-(hydroxymethyl)-1-piperazinecarboxylate
(2R)-2-(hydroxymethyl)-1-Piperazinecarboxylic acid tert-butyl ester
1-Piperazinecarboxylic acid, 2-(hydroxymethyl)-, 1,1-dimethylethyl ester, (2R)-
(R)-1-N-Boc-2-(hydroxymethyl)piperazine###(R)-2-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER | [Molecular Formula]
C10H20N2O3 | [MDL Number]
MFCD07772092 | [MOL File]
169448-87-7.mol | [Molecular Weight]
216.28 |
| Chemical Properties | Back Directory | [Boiling point ]
324.0±17.0 °C(Predicted) | [density ]
1.085±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
14.97±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
(R)-tert-Butyl 2-(hydroxymethyl)piperazine-1-carboxylate is used in preparation of novel substituted quinoline-8-carbonitrile derivatives with androgen receptor degradation activity and uses thereof. | [Synthesis]
Lithium aluminum hydride (1M in THF, 26 ml) was added to a solution of L-TERT- butyl 2-methyl (2R)-piperazine-1, 2-dicarboxylate (2. 55 g) in THF (70 ml) at-40°C, and then the reaction was warmed to room temperature. After stirring for 1 h, this reaction system was cooled to 0°C and quenched by sequential addition of water (1 ml), sodium hydroxide (2N, 1 ml), and then water (2 ml). The resulting slurry was filtered and concentrated in vacuo to give (R)-1-N-Boc-2-(hydroxymethyl)piperazine.
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