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ChemicalBook--->CAS DataBase List--->164391-47-3

164391-47-3

164391-47-3 Structure

164391-47-3 Structure
IdentificationBack Directory
[Name]

4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
[CAS]

164391-47-3
[Synonyms]

Zinc00005777
Immepip hydrobromide
IMMEPIP DIHYDROBROMIDE
4-(1H-Imidazol-5-ylmethyl)piperidine hydrobromide
4-(1H-IMIDAZOL-4-YLMETHYL)PIPERIDINE DIHYDROBROMIDE
Piperidine,4-(1H-imidazol-4-ylmethyl)-,dihydrobromide
[Molecular Formula]

C9H17Br2N3
[MDL Number]

MFCD06407876
[MOL File]

164391-47-3.mol
[Molecular Weight]

327.06
Chemical PropertiesBack Directory
[Appearance]

Crystalline Solid
[Melting point ]

234-235℃
[storage temp. ]

2-8°C
[solubility ]

H2O: 7 mg/mL at <40 °C
[form ]

solid
[color ]

light tan
[Water Solubility ]

Soluble to 100 mM in water
Hazard InformationBack Directory
[Chemical Properties]

Crystalline Solid
[Uses]

A selective nonchiral histamine H3 agonist
[Biological Activity]

Potent histamine H 3 receptor agonist. Also binds to H 4 receptors (K i values are 0.4 and 9 nM at human recombinant H 3 and H 4 receptors respectively). Equipotent to or slightly more active than (R)- α -methylhistamine at H 3 receptors.
[Description]

Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor). It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor). Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats. It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.
[storage]

Desiccate at RT
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
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