| Identification | Back Directory | [Name]
L-Valinamide, N-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-alanyl-L-alanyl-L-asparaginyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1... | [CAS]
1638970-46-3 | [Synonyms]
L-Valinamide, N-[[[4-[[N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-alanyl-L-alanyl-L-asparaginyl]amino]phenyl]methoxy]carbonyl]-N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1... | [Molecular Formula]
C67H101N11O16 | [Molecular Weight]
1316.58 |
| Chemical Properties | Back Directory | [Boiling point ]
1421.2±65.0 °C(Predicted) | [density ]
1.217±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO : 180 mg/mL (136.72 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.15±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) is a potent anticancer agent, which can be specific activated by tumor microenvironment. Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE can suppress tumor growth in mice (extracted from patent CN104147612A)[1].
Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE (compound S6) (26.2 micro-rubbing/kg, IV, weekly for 4 weeks) suppresses tumor growth in mice bearing Panc-1 tumor[1]. | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1]. Liu Chen, et al. Tumor microenvironment specific activated micromolecular targeted conjugate and application thereof. CN104147612A. |
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