| Identification | Back Directory | [Name]
lygtf | [CAS]
1632051-40-1 | [Synonyms]
217
lygtf
CS-2797
SAGE-217
Zuranolone
SAGE-217; SAGE 217; SAGE217;1632051-40-1
1H-Pyrazole-4-carbonitrile, 1-[(3α,5β)-3-hydroxy-3-methyl-20-oxo-19-norpregnan-21-yl]-
1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile | [Molecular Formula]
C25H35N3O2 | [MDL Number]
MFCD31619241 | [MOL File]
1632051-40-1.mol | [Molecular Weight]
409.56 |
| Chemical Properties | Back Directory | [Boiling point ]
574.3±30.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml; DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
15.17±0.60(Predicted) | [InChIKey]
HARRKNSQXBRBGZ-BOBURQISNA-N | [SMILES]
C[C@]12CC[C@]3([H])[C@@]4([H])CC[C@](O)(C)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@@H]2C(=O)CN1N=CC(C#N)=C1 |&1:1,4,6,10,14,18,20,24,r| |
| Hazard Information | Back Directory | [Uses]
Zuranolone is a potent GABAA receptor agonist. | [Definition]
Zuranolone is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor-positive modulator, and the first oral medication indicated to treat postpartum depression in adults 2. | [Mechanism of action]
The mechanism of action of zuranolone in treating PPD is not fully understood but is thought to be related to its positive allosteric modulation of GABAA receptors. Unlike benzodiazepines, another class of GABAA positive modulators, zuranolone binds to the α/β subunit interface presented in all GABAA receptors instead of the α/γ subunit interface. Therefore, zuranolone can bind to both synaptic GABAA receptors, composed of 2α2βγ subunits, and extrasynaptic GABAA receptors, composed of 2α2βδ subunits.
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