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ChemicalBook--->CAS DataBase List--->162012-70-6

162012-70-6

162012-70-6 Structure

162012-70-6 Structure
IdentificationBack Directory
[Name]

4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
[CAS]

162012-70-6
[Synonyms]

4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE
4-chloro-6-nitro-7-fluoro-quinazoline
Quinazoline, 4-chloro-7-fluoro-6-nitro-
4-CHLORO-7-FLUORO-6-NITRO-QUINAZOLINE###162012-70-6
Afatinib impurity 6: 4-chloro-7fluoro-6-nitroquinazoline
[Molecular Formula]

C8H3ClFN3O2
[MDL Number]

MFCD08063159
[MOL File]

162012-70-6.mol
[Molecular Weight]

227.58
Chemical PropertiesBack Directory
[Boiling point ]

395℃
[density ]

1.649
[Fp ]

193℃
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[pka]

0.53±0.70(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H319
[Precautionary statements ]

P305+P351+P338
[Hazard Codes ]

Xn
[Risk Statements ]

22-36
[Safety Statements ]

26
Hazard InformationBack Directory
[Uses]

4-Chloro-7-fluoro-6-nitroquinazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
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