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ChemicalBook--->CAS DataBase List--->1616426-12-0

1616426-12-0

1616426-12-0 Structure

1616426-12-0 Structure
IdentificationBack Directory
[Name]

H2N-PEG11-CH2CH2COOH
[CAS]

1616426-12-0
[Synonyms]

Amino-PEG11-COOH
Amino-PEG11-acid
H2N-PEG11-CH2CH2COOH
Amino-PEG11-propionic acid
[Molecular Formula]

C25H51NO13
[MOL File]

1616426-12-0.mol
[Molecular Weight]

573.67
Hazard InformationBack Directory
[Biological Activity]

Amino-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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