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ChemicalBook--->CAS DataBase List--->161552-03-0

161552-03-0

161552-03-0 Structure

161552-03-0 Structure
IdentificationBack Directory
[Name]

CYCLO (ARG-GLY-ASP-D-PHE-LYS)
[CAS]

161552-03-0
[Synonyms]

CYCLO
c(RGDfK)
CYCLO(-RGDFK)
cyclo(RGD-DPhe-K)
Cyclo (-RGDfK) TFA
Cyclo(-RGDfK), >98%
Cyclo(RGDfK) peptide
Cyclic RGDFK peptide
C(RGDFK);CYCLO (RGDFK)
Cyclo(-RGDfK)(free base)
cyclo (Arg-Gly-Asp-Phe-Lys)
CYCLO (ARG-GLY-ASP-D-PHE-LYS)
CYCLO (ARG-GLY-ASP-D-PHE-LYS) USP/EP/BP
CYCLO(RGDFK) PEPTIDE;CYCLIC RGDFK PEPTIDE
Cyclo(-Arg-Gly-Asp-D-Phe-Lys) Trifluoroacetate salt
Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-lysyl)
Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-L-lysyl)
Cyclo(-RGDfK),inhibit,Microvasculature,cancer,Integrin,tumoral cell,αvβ3 integrin,Cyclo(RGDfK),ligand,Inhibitor,Cyclo( RGDfK)
[Molecular Formula]

C27H41N9O7
[MDL Number]

MFCD00937400
[MOL File]

161552-03-0.mol
[Molecular Weight]

603.67
Chemical PropertiesBack Directory
[Melting point ]

191℃ (decomposition)
[density ]

1.47±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

≥30.19 mg/mL in DMSO; insoluble in EtOH; ≥59.2 mg/mL in H2O
[form ]

Powder
[pka]

4.01±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Cyclo (-RGDfK) Trifluoroacetic Acid Salt is a potent inhibitor of αvβ3 integrin. Used in tumor therapy due to the targeting of the VEGFR2 gene by sRNA.
[Biological Activity]

in one study where this peptide was labeled with 125i, it was found to bind specifically and with high affinity to αvβ3 receptors on neovascular blood vessel sections of different major human cancers. the integrin alpha(iib)beta(3)-specific cyclic hexapeptide contains an arg-gly-asp (rgd) sequence.
[target]

Integrin
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

CYCLO (ARG-GLY-ASP-D-PHE-LYS)(161552-03-0)MS
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