| Identification | Back Directory | [Name]
(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide | [CAS]
1609465-89-5 | [Synonyms]
PF-06250112
PF06250112,PF 06250112
(R)-5-Amino-1-(1-cyanopiperidin-3-yl)-3-(4-[2,4-difluorophenoxy]phenyl)-1H-pyrazole-4-carboxamide
1H-Pyrazole-4-carboxamide, 5-amino-1-[(3S)-1-cyano-3-piperidinyl]-3-[4-(2,4-difluorophenoxy)phenyl]- | [Molecular Formula]
C22H20F2N6O2 | [MDL Number]
MFCD28100804 | [MOL File]
1609465-89-5.mol | [Molecular Weight]
438.43 |
| Chemical Properties | Back Directory | [Boiling point ]
643.6±55.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
14.99±0.50(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Biological Activity]
PF-06250112 is a potent inhibitor of Brutonμs tyrosine kinase (BTK). PF-06250112 blocks both B-cell receptor and FcR-mediated signalingand prevents FcR-dependentAntibody-mediated proteinuria in a mouse glomerulonephritis model. |
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MedChemExpress
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www.medchemexpress.com |
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