| Identification | Back Directory | [Name]
Hs 27 | [CAS]
1562024-11-6 | [Synonyms]
Hs 27
HS27;HS-27;HS 27
2-((1-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9,-xanthen]-5-yl)amino)-1-thio,HS-27
2-((1-((3',6'-DIHYDROXY-3-OXO-3H-SPIRO[ISOBENZOFURAN-1,9,-XANTHEN]-5-YL)AMINO)-1-THIOXO-6,9,12,15,18-PENTAOXA-2-AZAHENICOSAN-21-YL)AMINO)-4-(3,6,6-TRIMETHYL-4-OXO-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL)BENZAMIDE,HS-27
Benzamide, 2-[[21-[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)amino]-21-thioxo-4,7,10,13,16-pentaoxa-20-azaheneicos-1-yl]amino]-4-(4,5,6,7-tetrahydro-3,6,6-trimethyl-4-oxo-1H-indazol-1-yl)- | [Molecular Formula]
C52H60N6O12S | [MDL Number]
MFCD32173434 | [MOL File]
1562024-11-6.mol | [Molecular Weight]
993.13 |
| Chemical Properties | Back Directory | [Boiling point ]
1095.1±75.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
-196°C | [solubility ]
DMSO: 125 mg/mL (125.86 mM) | [form ]
Solid | [pka]
9.33±0.20(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Biological Activity]
HS-27, a fluorescent Hsp90 inhibitor, detects Hsp90 expression on the surface of intact tissue specimens. It consists of the core elements of SNX-5422, an Hsp90 inhibitor linked via a PEG linker to a fluorescein derivative (fluorescein isothiocyanate or FITC) that binds to peripherally expressed Hsp90 combine. | [in vitro]
HS-27 labels all receptor subtypes of breast cancer, but not normal cells, and specifically binds to Hsp90 expressed on the surface of breast cancer cells before being internalized. | [target]
| [storage]
Store at -20°C |
|
| Company Name: |
DC Chemicals
|
| Tel: |
021-58447131 13564518121 |
| Website: |
http://www.is0513.com/ShowSupplierProductsList927327/0.htm |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
|