| Identification | Back Directory | [Name]
BLU 9931 | [CAS]
1538604-68-0 | [Synonyms]
BLU
CS-1699
BLU9931
LM-3610
BLU-9931
BLU 9931
LM-3610; BLU9931
BLU 9931;BLU-9931
BLU-9931;BLU 9931;BLU9931
BLU9931, 98%, a potent, selective, and irreversible FGFR4 inhibitor
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]-2-propenamide
2-Propenamide,N-[2-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]- | [Molecular Formula]
C26H22Cl2N4O3 | [MDL Number]
MFCD28900729 | [MOL File]
1538604-68-0.mol | [Molecular Weight]
509.38 |
| Chemical Properties | Back Directory | [density ]
1.361±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥50.9 mg/mL in DMSO; insoluble in H2O; ≥2.53 mg/mL in EtOH with gentle warming and ultrasonic | [form ]
Powder | [pka]
13.15±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Definition]
BLU9931 is a potent, highly selective, and irreversible fibroblast growth factor receptor 4 (FGFR4) inhibitor with an IC50 of 3 nM and a Kd of 6 nM. BLU9931 has significant antitumor activity. BLU9931 makes a covalent bond with Cys552 within the ATP-binding pocket of FGFR4, which is not present in FGFR1-3. BLU9931 inhibited gastric cancer cell growth in a transplanted mouse model[1].
| [References]
[1] Norihiko Sasaki. “FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.” Cancers (2020).
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