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ChemicalBook--->CAS DataBase List--->153653-30-6

153653-30-6

153653-30-6 Structure

153653-30-6 Structure
IdentificationBack Directory
[Name]

Dofequidar fuMarate
[CAS]

153653-30-6
[Synonyms]

Dofequidar (2E)-2-butenedioate (1:1)
[Molecular Formula]

C34H35N3O7
[MDL Number]

MFCD00925095
[MOL File]

153653-30-6.mol
[Molecular Weight]

597.658
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

White to off-white
Hazard InformationBack Directory
[Biological Activity]

dofequidar fumarate is a multidrug-resistant (mdr) - reversal agent [1].dofequidar fumarate is a quinoline derivative and has highly potent reversing effect on multidrug-resistant tumor cells. it prevents the transport of antitumor drugs through interacting with the drug-efflux pump p-glycoprotein directly and thereby reverses mdr. in vincristine (vcr)-resistant p388/vcr cells and adriamycin (adm)- resistant p388/adm cells, dofequidar fumarate at 1μm and 3μm can completely reverse the drug resistance. it also shows significant effects on the mdr k562 cells. furthermore, in mice model bearing hct-15 xenografts, combination therapy of dofequidar fumarate and docetaxel induces remarkable tumor growth inhibition. dofequidar fumarate also shows significant reversing effect in mcf-7/adm-bearing mice [1, 2].
[References]

[1] sato w, fukazawa n, nakanishi o, et al. reversal of multidrug resistance by a novel quinoline derivative, ms-209. cancer chemotherapy and pharmacology, 1995, 35(4): 271-277.
[2] naito m, matsuba y, sato s, et al. ms-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. clinical cancer research, 2002, 8(2): 582-588.
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