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ChemicalBook--->CAS DataBase List--->153559-76-3

153559-76-3

153559-76-3 Structure

153559-76-3 Structure
IdentificationBack Directory
[Name]

6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
[CAS]

153559-76-3
[Synonyms]

LG 268
CD 3127
ALRT 268
lg100268
LGD 1268
LGD 100268
AGN 192620
hthalenyl)cyclopropyl)-
3-pyridinecarboxylicacid,6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-nap
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid
6-[1-(3,5,5,8,8-PentaMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid
3-Pyridinecarboxylicacid,6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)cyclopropyl]-
6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]- 3-Pyridinecarboxylic Acid
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID (FOR R&D ONLY)
[Molecular Formula]

C24H29NO2
[MDL Number]

MFCD01758574
[MOL File]

153559-76-3.mol
[Molecular Weight]

363.49
Chemical PropertiesBack Directory
[Appearance]

Off-White Solid
[Melting point ]

275-277°C
[Boiling point ]

487.0±33.0 °C(Predicted)
[density ]

1.115±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

DMSO: ≥5mg/mL (warmed)
[form ]

powder
[pka]

2.35±0.10(Predicted)
[color ]

white to beige
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Uses]

LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
[Biochem/physiol Actions]

LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
[storage]

Store at -20°C
Safety DataBack Directory
[WGK Germany ]

3
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