| Identification | Back Directory | [Name]
DICLOFENAC-D4 | [CAS]
153466-65-0 | [Synonyms]
DICLOFENAC-D4
Diclofenac-D4 (Major)
DICLOFENAC-D4 (PHENYL-D4)
2-((2,6-Dichlorophenyl)aminobenzeneacetic Acid-d4, | [Molecular Formula]
C14H7Cl2D4NO2 | [MDL Number]
MFCD06658788 | [MOL File]
153466-65-0.mol | [Molecular Weight]
300.17 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Crystalline Solid | [Melting point ]
157-159°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO: 35 mg/ml,Ethanol: 35 mg/ml,PBS (pH 7.2): 6 mg/ml | [form ]
A solid | [color ]
White to off-white | [Water Solubility ]
Water: 50 mg/ml | [CAS DataBase Reference]
153466-65-0 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Crystalline Solid | [Uses]
Labeled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
92% overall isotopic purity. A representative lot was 75% d4, 23% d3 and 2 % d2 | [Uses]
Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. | [Uses]
Labelled Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.
| [Description]
Diclofenac-d4 is intended for use as an internal standard for the quantification of diclofenac (Item Nos. 70680 | 22983) by GC- or LC-MS. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. | [storage]
Store at Room temperature |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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