| Identification | Back Directory | [Name]
14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid | [CAS]
149402-51-7 | [Synonyms]
Sulcardine
Photochlor
Photochlor (HTTP)
Photochlor (HPPH)
2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a
3-Devinyl-3-(1'-hexyloxy)ethylpyropheophorbide A
14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-4-phorbine propanoic acid
14-Ethyl-9-(1-(hexyloxy)ethyl)-4,8,13,18-tetramethyl-20-oxo-3-phorbine propanoic acid
(3S,4S)-14-Ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18-tetramethyl-20-oxo-3-phorbinepropanoic acid
3-Phorbinepropanoic acid, 14-ethyl-9-[1-(hexyloxy)ethyl]-4,8,13,18 -tetramethyl-20-oxo-, (3S,4S)- | [Molecular Formula]
C39H48N4O4 | [MDL Number]
MFCD11040935 | [MOL File]
149402-51-7.mol | [Molecular Weight]
636.82 |
| Chemical Properties | Back Directory | [Boiling point ]
992.5±65.0 °C(Predicted) | [density ]
1.184 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO:3.0(Max Conc. mg/mL);4.7(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light brown to black |
| Hazard Information | Back Directory | [Description]
HPPH is a chlorin that acts as a photosensitizer in photodynamic therapy (PDT) when stimulated with light at 655 nm.1 When administered systemically, HPPH accumulates in tumor cells and, when stimulated with light in the presence of oxygen, reactive oxygen species (ROS) are generated, leading to necrosis within the tumor. HPPH, at a dose of 0.5 mg/kg, increases survival in a nude rat model of glioma.2 It works synergistically with gemcitabine (Item No. 11690) in several pancreatic cancer cell lines to induce cell death.3 | [Uses]
Photochlor is an anticancer photodynamic therapy drug that triggers multiple drug release and tumor killing cells in mouse breast cancer xenograft. Also functions as a photochlor-mediated photodynamic therapy for non-small cellular lung cancer treatment in murine model. | [storage]
4°C, away from moisture and light |
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