| Identification | Back Directory | [Name]
Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester | [CAS]
1480830-24-7 | [Synonyms]
OUP186
OUP-186
OUP 186
Carbamimidothioic acid, N-[4-(4-chlorophenyl)butyl]-, 3-(1-piperidinyl)propyl ester | [Molecular Formula]
C19H30ClN3S | [MOL File]
1480830-24-7.mol | [Molecular Weight]
367.98 |
| Hazard Information | Back Directory | [Description]
OUP-186 is a high affinity and humarat species-selective histamine H3 receptor antagonist. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R)-(-)-α-methylhistamine (H3R agonist). OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells. |
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