| Identification | Back Directory | [Name]
Hydroxypioglitazone | [CAS]
146062-44-4 | [Synonyms]
HYDROXYPIOGLITAZONE
Pioglitazone, hydroxy M-IV
Hydroxy Pioglitazone (M-IV)
5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY] PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE | [Molecular Formula]
C19H20N2O4S | [MDL Number]
MFCD00916074 | [MOL File]
146062-44-4.mol | [Molecular Weight]
372.44 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
157-1580C | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [CAS DataBase Reference]
146062-44-4 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A metabolite of Pioglitazone (P471000). | [Description]
Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM). | [Definition]
ChEBI: Hydroxypioglitazone is a member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. It has a role as a human xenobiotic metabolite. It is a member of thiazolidinediones, a member of pyridines and an aromatic ether. It is functionally related to a pioglitazone. | [storage]
Store at -20°C |
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