| Identification | Back Directory | [Name]
MPEG5-NHS | [CAS]
1449390-12-8 | [Synonyms]
MPEG5-NHS
mPEG6-NHS
mPEG5-SPA
m-PEG6-NHS ester
Methyl-PEG5-NHS ester
mPEG5-CH2CH2COONHS Ester
4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester | [Molecular Formula]
C18H31NO10 | [MDL Number]
MFCD27977519 | [MOL File]
1449390-12-8.mol | [Molecular Weight]
421.44 |
| Chemical Properties | Back Directory | [Boiling point ]
502.6±60.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
m-PEG6-NHS ester is a PEG linker containing an NHS ester. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer increases solubility in aqueous media. | [Biological Activity]
MPEG5-NHS is a non-cleavable 6-unit PEG-containing ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG/Alkyl/ether class, which can be used to synthesize PROTAC molecules. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| PEGs | Alkyl/ether | Non-cleavable | |
|
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