| Identification | Back Directory | [Name]
GR 113808 | [CAS]
144625-51-4 | [Synonyms]
GR 113808
1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE
1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles
1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER
1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester
GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808 | [Molecular Formula]
C19H27N3O4S | [MDL Number]
MFCD00912901 | [MOL File]
144625-51-4.mol | [Molecular Weight]
393.5 |
| Chemical Properties | Back Directory | [Boiling point ]
572.3±53.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 44 mg/mL, soluble
| [form ]
solid
| [pka]
11.22±0.40(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish. | [Definition]
ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide. | [Biological Activity]
Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors. | [Biochem/physiol Actions]
GR 113808 is a 5-HT4 serotonin receptor antagonist. | [storage]
Store at RT |
|
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