| Identification | Back Directory | [Name]
TIN PROTOPORPHYRIN IX DICHLORIDE | [CAS]
14325-05-4 | [Synonyms]
SnPPIX
Nsc267099
TINPROTOPORPHYRIN
tin protoporphyrin IX
TIN PROTOPORPHYRIN IX DICHLORIDE
Tin Protoporphyrin IX (chloride)
Stannate(2-) dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid] | [Molecular Formula]
C34H36Cl2N4O4Sn | [MDL Number]
MFCD00673909 | [MOL File]
14325-05-4.mol | [Molecular Weight]
754.29 |
| Hazard Information | Back Directory | [Uses]
Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. TIN PROTOPORPHYRIN IX DICHLORIDE(SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.[Cayman Chemical]
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| Company Name: |
Alfa Chemistry
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| Tel: |
1-516-6625404 |
| Website: |
https://www.alfa-chemistry.com |
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