| Identification | Back Directory | [Name]
WEHI-539 | [CAS]
1431866-33-9 | [Synonyms]
CS-1739
WEHI-539
WEHI539;WEHI 539
WEHI-539 ( CT-WE539)
(E)-5-(3-(4-(Aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetr
5-[3-[4-(Aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]-4-thiazolecarboxylic acid
(E)-5-(3-(4-(aminomethyl)phenoxy)propyl)-2-(8-(2-(benzo[d]thiazol-2-yl)hydrazono)-5,6,7,8-tetrahydronaphthalen-2-yl)thiazole-4-carboxylic acid
4-Thiazolecarboxylic acid, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[8-[2-(2-benzothiazolyl)hydrazinylidene]-5,6,7,8-tetrahydro-2-naphthalenyl]- | [Molecular Formula]
C31H29N5O3S2 | [MDL Number]
MFCD25372044 | [MOL File]
1431866-33-9.mol | [Molecular Weight]
583.72 |
| Chemical Properties | Back Directory | [Boiling point ]
827.6±75.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in DMSO; insoluble in H2O; insoluble in EtOH | [form ]
solid | [pka]
10.24±0.20(Predicted) |
| Hazard Information | Back Directory | [Uses]
WEHI 539 is a selective BCL-XL inhibitor. | [Biological Activity]
wehi-539 is a small-molecule inhibitor of bclxlwith an ic50 value of 1.1 nm [1].wehi-539 was designed as a bcl-xlinhibitor with high affinity. it interacted the with the binding groove of bcl-xlwith a kd value of 0.6 nm. in mef cells lacking mcl-1, wehi-539 induced apoptosis which was evidenced by the release of mitochondrial cytochrome cand caspase-3 processing. in bcl-xloverexpressed mef cells, wehi-539 showed ec50 value of 0.48 μm. wehi-539 also significantly induced apoptosis of the platelets purified from mice. besides that, wehi-539can not kill mef cells lacking bak because the cell death mediator bak is regulated by bcl-xland mcl-1. [1]. | [target]
BCL-XL | [storage]
Store at -20°C | [References]
[1] lessene g, czabotar p e, sleebs b e, et al. structure-guided design of a selective bcl-xl inhibitor. nature chemical biology, 2013, 9(6): 390-397. |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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