成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->1430844-80-6

1430844-80-6

1430844-80-6 Structure

1430844-80-6 Structure
IdentificationBack Directory
[Name]

A-1331852
[CAS]

1430844-80-6
[Synonyms]

CS-2498
A-1331852
A 1331852;A1331852
6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-(adamantylmethyl)-5-methyl-1H-pyrazol-4-yl)picolinic acid
6-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]pyridine-2-carboxylic acid
2-Pyridinecarboxylic acid, 6-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-3-[5-methyl-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazol-4-yl]-
[Molecular Formula]

C38H38N6O3S
[MDL Number]

MFCD30532662
[MOL File]

1430844-80-6.mol
[Molecular Weight]

658.81
Chemical PropertiesBack Directory
[Melting point ]

>161oC (dec.)
[density ]

1.50±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Acetonitrile (Slightly, Heated), DMSO (Slightly)
[form ]

Solid
[pka]

8.88±0.70(Predicted)
[color ]

Pale Yellow to Light Beige
Hazard InformationBack Directory
[Description]

A-1331852 is an orally bioavailable Bcl-xL inhibitor that selectively binds Bcl-xL over Bcl-2, Mcl-1, and Bcl-W (Kis = <0.01, 6, 142, and 4 nM, respectively). It inhibits growth of Bcl-xL-dependent MOLT-4, but not Bcl-2-dependent RS4;11, acute lymphocytic leukemia cells in vitro (EC50s = 6 and >5,000 nM, respectively). A-1331852 (25 mg/kg twice per day) inhibits tumor growth in a MOLT-4 mouse xenograft model. It also inhibits tumor growth and increases the antitumor activity of docetaxel (Item No. 11637) in MDA-MB-231 LC3 metastatic breast cancer and NCI-H1650 non-small cell lung cancer mouse xenograft models when administered at a dose of 25 mg/kg. A-1331852 also increases venetoclax inhibition of tumor growth in an NCI-H1963.FP5 small cell lung cancer mouse xenograft model.
[Uses]

A-1331852 is a substituted benzothiazole that can serve as an anti-apoptotic Bcl-xL protein inhibitor and apoptosis-inducing agent useful in the treatment of cancer, immune and autoimmune diseases.
[in vitro]

a-1331852 was identified as a potent bcl-xl inhibitor demonstrating cellular activity 10- to 50-fold more potent than its analog a-1155463 and the previouly reported bcl-xl inhibitor, navitoclax, respectively. moreover, a-1331852 could selectively disrupt bcl-xl–bim complexes and induce the apoptosis hallmarks in bcl-xl–dependent molt-4 cells with median ic50 values in the low nanomolar range but did not affect mef cells without bak or bax [1].
[in vivo]

previous animal study found that a-1331852 could demonstrate antitumor efficacy in the molt-4 xenograft model, such as tumor regressions as a single agent. in addition, in the nci-h1963.fp5 xenograft model of sclc, it was found that a-1331852 combined with venetoclax was able to recapitulate the efficacy of navitoclax [1].
[storage]

Store at -20°C
[References]

[1] leverson jd et al. exploiting selective bcl-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. sci transl med. 2015 mar 18;7(279):279ra40. doi: 10.1126/scitranslmed.aaa4642.
Spectrum DetailBack Directory
[Spectrum Detail]

A-1331852(1430844-80-6)MS
1430844-80-6 suppliers list
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: Zhengzhou Alfa Chemical Co.,Ltd
Tel: +8618530059196 , +8618530059196
Website: http://www.is0513.com/manufacturer/zhengzhou-alfa-chemical-276/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226 , 13588875226
Website: www.hzclap.com/en
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Nanjing Doge Biomedical Technology Co., Ltd
Tel: +86-25-58227606 +86-15305155328 , +86-15305155328
Website: https://www.dogechemical.com
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Chemtour Biotech Co., Ltd
Tel: +8617327281506 , +8617327281506
Website: www.chemtour.com
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Website: www.leapchem.com
Company Name: Sichuan Biosynce Pharmatech Co., Ltd.
Tel: +8619950309693 , +8619950309693
Website: www.biosynce-product.com
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Website: www.aladdinsci.com/
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Shanghai Luofa Biochemical Technology Co., Ltd.  Gold
Tel: 021-51111890 15317326293
Website: www.molnova.cn/
Company Name: Shanghai YuanQi Biotechnology Co., Ltd.  Gold
Tel: +86-2332782371 +86-18120098618
Website: http://www.is0513.com/ShowSupplierProductsList16784/0.htm
Company Name: SuZhou GoodChemTech Co., Ltd  Gold
Tel: 18136139868
Website:
Company Name: Chembest Research Laboratories Limited  
Tel: +86-21-20908456
Website: http://www.BioChemBest.com
Company Name: MedChemexpress LLC  
Tel: 021-58955995
Website: www.medchemexpress.cn
Tags:1430844-80-6 Related Product Information
26166-39-2 35482-50-9