| Identification | Back Directory | [Name]
NARIRUTIN | [CAS]
14259-46-2 | [Synonyms]
NARIRUTIN
Aids089292
Aids-089292
ISONARINGIN
NARIRUTIN(P)
NARIRUTIN(RG)
Isonaringenin
NARIRUTIN hplc
(2S)-Narirutin
Narirutin (8CI)
Narirutin Standard
NARIRUTIN WITH HPLC
Naringenin impurities1
NARINGENIN-7-RUTINOSIDE
NARINGENIN-7-O-RUTINOSIDE
Narirutin, froM Citrus MaxiMa
Diosmin Impurity 21 (Narirutin)
NARINGEN EXTRACT (CITRUS PARADISI MACF.)
Narirutin, 98%, from Citrus maxima (Burm.) Merr.
(S)-7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosy...
(S)-7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
(2S)-7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2α-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
(S)-7-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 7-6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyloxy-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
5-Hydroxy-2-(4-hydroxy-phenyl)-7-[3,4,5-trihydroxy-6-(3,4,5-trihydroxy-6-methyl-tetrahydro-pyran-2-yloxymethyl)-tetrahydro-pyran-2-yloxy]-1-benzopyran-4-one
NarirutinQ: What is
Narirutin Q: What is the CAS Number of
Narirutin Q: What is the storage condition of
Narirutin Q: What are the applications of
Narirutin
(2S)-5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3-dihydrochromen-4-one
(S)-5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)chroman-4-one | [EINECS(EC#)]
238-138-0 | [Molecular Formula]
C27H32O14 | [MDL Number]
MFCD00017316 | [MOL File]
14259-46-2.mol | [Molecular Weight]
580.53 |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
(2S)-Narirutin is a naturally occurring flavonoid that possess anti-allergic, anti-inflammatory, antiproliferative and anti-oxidant properties | [Definition]
ChEBI: A disaccharide derivative that is (S)-naringenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a
lycosidic linkage. | [Biological Activity]
Narirutin is known to possess anti-allergicanti-inflammatoryantioxidantand anti-proliferative properties. It inhibits allergic eosinophilic airway inflammation in the mouse model. Narirutin also inhibits lipopolysaccharide (LPS)-induced inflammatory response by inhibiting nuclear factor-KB (NF-KB) and mitogen-activated protein kinases (MAPKs). It displays antioxidant and protective effects on attenuating alcohol-induced liver damage while co-consumed with alcohol in mice modeland can be useful in Alzheimerμs disease (AD) therapeutics. | [in vivo]
Narirutin (10 mg/kg, p.o ) reduces eosinophil counts in peripheral blood in OVA-challenged mice[2].
Narirutin (10 mg/kg, p.o ) block the OVA-induced increase in IL-4 but has no effect on the increase in IL-5[2].
| Animal Model: | Allergic asthma female NC/Nga mice model[2] | | Dosage: | 0.1, 1 or 10 mg/kg | | Administration: | Orally, 7d | | Result: | Reduced eosinophil counts in peripheral blood.
Blocked the OVA-induced increase in IL-4.
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