| Identification | Back Directory | [Name]
IRL-1620 | [CAS]
142569-99-1 | [Synonyms]
IRL-1620
SPI-1620
Sovateltide
IRL-1620, HUMAN
28: PN: WO2007112069 SEQID
M.W. 1820.97 C86H117N17O27
SUC-[GLU9, ALA11,15]-ENDOTHELIN-1 (8-21)
N-SUC-[GLU9, ALA11,15]ENDOTHELIN-I (8-21)
ENDOTHELIN-1(8-21), N-SUC-[GLU9, ALA11,15]
SUCCINYL-(GLU9,ALA11,15)-ENDOTHELIN-1 (8-21)
N-SUCCINYL-[GLU9, ALA11,15]-ENDOTHELIN, 8-21
SUC-[GLU9, ALA11, 15] ENDOTHELIN-1 (8-21), HUMAN
Endothelin-1 (8-21), succinyl-(Glu(9),Ala(11,15))-
Succinyl-(Glu9,Ala1115)-Endothelin-1 (8-21), IRL-1620
n-succinyl-[glu9, ala11,15]-endothelin 1 fragment 8-21
Succinyl-(glutamyl(9)-alanyl(11,15))-endothelin-1 (8-21)
SUC-ASP-GLU-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP
N-Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
SUC-ASP-GLU-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH
IRL-1620;N-SUCCINYL-[GLU9, ALA11,15]-ENDOTHELIN 1 FRAGMENT 8-21
IRL-1620(ENDOTHELIN-1(8-21), N-SUC-(GLU9 ,ALA11,15) SYNTHETIC >97%
SUC-ASP-GLU-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP: SUC-DEEAVYFAHLDIIW
IRL-1620, N-Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp, N-Succinyl-[Glu9, Ala11,15]-Endothelin1 fragment 8-21
L-Tryptophan, N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-
L-Tryptophan, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-tyrosyl-L-alanyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-
N-(3-Carboxy-1-oxopropyl)-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan | [Molecular Formula]
C86H117N17O27 | [MDL Number]
MFCD00214284 | [MOL File]
142569-99-1.mol | [Molecular Weight]
1820.95 |
| Chemical Properties | Back Directory | [Boiling point ]
2096.6±65.0 °C(Predicted) | [density ]
1.347±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
powder
| [pka]
3.39±0.10(Predicted) | [color ]
white
| [Water Solubility ]
Soluble in water (0.5 mg/ml) | [Sequence]
Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH |
| Hazard Information | Back Directory | [Biological Activity]
IRL-1620 is a potent and selective endorphin receptor (endothelin receptor) type B agonist with a Ki of 16 pM. | [in vitro]
IRL-1620 is the most potent and specific ligand for the ETB receptor (K i ETA/ K i ETB=120,000) as judged by the K i values for ETA (19 μM) and ETB (16 PM) receptors. IRL-1620 is 60 times more selective for the ETB receptor than ET-3 (K i ETA /K i ETB=1,900). | [target]
IC50: 16 pM (Endothelin receptor B), 19 μM (Endothelin receptor A) | [storage]
Store at -20°C |
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