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ChemicalBook--->CAS DataBase List--->142057-80-5

142057-80-5

142057-80-5 Structure

142057-80-5 Structure
IdentificationBack Directory
[Name]

(-)-Donepezil
[CAS]

142057-80-5
[Synonyms]

S-(-)-DONEPEZIL
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, (2S)-
[Molecular Formula]

C24H29NO3
[MOL File]

142057-80-5.mol
[Molecular Weight]

379.49
Chemical PropertiesBack Directory
[Melting point ]

108-110°C
[Boiling point ]

527.9±50.0 °C(Predicted)
[density ]

1.141±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

8.84±0.10(Predicted)
[color ]

White to Off-White
Hazard InformationBack Directory
[Uses]

(-)-Donepezil is an isomer of Donepezil (D531750), a nootropic, acting as an inhibitor of acetylcholinesterase.
[Definition]

ChEBI: Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. It contains a (R)-donepezil and a (S)-donepezil. It is a conjugate base of a donepezil (1+).
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