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ChemicalBook--->CAS DataBase List--->1402821-41-3

1402821-41-3

1402821-41-3 Structure

1402821-41-3 Structure
IdentificationBack Directory
[Name]

GV-58
[CAS]

1402821-41-3
[Synonyms]

GV-58
GV-58 >=97% (HPLC)
(2R)-2-[[6-[[(5-Methylthiophen-2-yl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]butan-1-ol
1-Butanol, 2-[[6-[[(5-methyl-2-thienyl)methyl]amino]-9-propyl-9H-purin-2-yl]amino]-, (2R)-
[Molecular Formula]

C18H26N6OS
[MDL Number]

MFCD28385865
[MOL File]

1402821-41-3.mol
[Molecular Weight]

374.5
Chemical PropertiesBack Directory
[Boiling point ]

599.6±60.0 °C(Predicted)
[density ]

1.33±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 50 mg/mL (133.51 mM);Water : < 0.1 mg/mL (insoluble)
[form ]

solid
[pka]

14.56±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P305+P351+P338
Hazard InformationBack Directory
[Biological Activity]

GV-58 is a roscovitine analog th at retains the ability to prolong the open state of calcium channelsbut unlike roscovitineis inactive against Cdk activity. GV-58 is a selective agonist of N-type and P/Q type calcium channelswhich are critical to the triggering of neurotransmitter release at the neuromuscular junction. GV-58 has been studied as a possible therapeutic agent in a mouse model of Lambert-Eaton myasthenic syndrome (LEMS). The EC50 values for activation of N-P/Q- and L- type calcium channels are 6.89.9 and >100 μMrespectively.
[storage]

+4°C
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