| Identification | Back Directory | [Name]
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester | [CAS]
1401089-31-3 | [Synonyms]
PACMA 31
PACMA 31 >=98% (HPLC)
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester | [Molecular Formula]
C21H22N2O6S | [MDL Number]
MFCD26793891 | [MOL File]
1401089-31-3.mol | [Molecular Weight]
430.47 |
| Hazard Information | Back Directory | [Uses]
PACMA 31 is a protein disulfide isomerase family A member 1 (PDIA1) inhibitor as promising target for chemotherapy. | [Biochem/physiol Actions]
PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model. | [storage]
Store at RT |
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